Anxiolytic / Anticonvulsant  ·  Benzodiazepine

Diazepam

Also known as: Valium, Diazep

A controlled medicine used short-term for anxiety, seizures, alcohol withdrawal, and muscle spasm, effective when used appropriately, with a well-established risk of dependence with prolonged use.

ATC CodeN05BA01
Kenya EML 2023Listed
Level of UseLevel 2-6
This is health education, not medical advice. Never start, stop, or change a medication without speaking to a qualified healthcare professional first.
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Controlled Medicine

Diazepam is a controlled substance in Kenya under the Narcotic Drugs and Psychotropic Substances Act. It requires a prescription from a registered prescriber.

Which conditions is Diazepam used for?

What is Diazepam?

Diazepam is a benzodiazepine medicine with several clinical uses: short-term management of severe anxiety, emergency treatment of seizures, management of alcohol withdrawal, and relief of muscle spasm. It is listed across multiple categories in Kenya's Essential Medicines List 2023 and is available from dispensary level.

It is effective for its intended purposes, but its use for anxiety and insomnia should be kept as brief as possible, ideally no longer than two to four weeks.

Diazepam is not a treatment for the underlying causes of anxiety or sleep problems. Psychological approaches and addressing life stressors are the foundation of long-term anxiety management.

What does it do in the brain?

Diazepam enhances the effect of GABA, the brain's main calming chemical messenger, by binding to GABA receptors and making them more responsive. This produces a widespread calming effect across the nervous system, which reduces anxiety, relaxes muscles, lowers seizure activity, and promotes sleep.

How is it available?

Tablet
2 mg, 5 mg
Taken by mouth
Widely available
Injection
5 mg/mL
Given by a healthcare professional
Available at hospital level

Where is it available in Africa and what is it called?

Names and availability vary by country. Always confirm with a local pharmacist or healthcare provider.
CountryCommon Brand Name(s)Notes
UgandaDiazepam (generic), ValiumOn the Uganda EML from health centre level; widely used for seizures, anxiety, and procedural sedation.
TanzaniaDiazepam (generic)On the Tanzania EML from dispensary level; widely available and commonly prescribed.
EthiopiaDiazepam (generic)On the Ethiopian EML; widely used for epilepsy and acute management across the health system.
RwandaDiazepam (generic)Available through the RBC pharmacy network from district hospital level.
South AfricaValium, Diazepam (generic)Widely available; dispensed in public sector for epilepsy and procedural use.
NigeriaValium, Diazepam (generic)Widely available across all government hospitals and private pharmacies.
GhanaDiazepam (generic)On the Ghana EML; available at all hospitals and health centres.
ZambiaDiazepam (generic)On the Zambia EML; available at district hospitals and above.

What might you feel while taking it?

These are the most commonly reported effects. Not everyone experiences them, and many settle within the first few weeks.

  • Drowsiness and sedation
  • Dizziness and impaired balance, increases the risk of falls, particularly in elderly people
  • Memory impairment
  • Muscle weakness
  • Slowed reaction time. Do not drive or operate machinery while taking it
  • Tolerance. The medicine becomes less effective with regular use over time
Go to a doctor or emergency room straight away if you notice any of the following.
  • Dependence, with use lasting longer than a few weeks, stopping becomes difficult
  • Breathing difficulty, particularly if combined with alcohol, opioid pain medicines, or other sedating substances
  • In some people, particularly elderly or young children, diazepam can cause paradoxical agitation

Important warnings before starting

Tell your doctor about all your medical conditions, allergies, and other medicines before starting Diazepam.
  • Significant breathing problems or sleep apnoea
  • Severe liver disease
  • Myasthenia gravis
  • You should not take diazepam if you have been drinking alcohol

Situations that need extra attention

  • Do not take diazepam with alcohol. The combination is dangerous
  • Do not drive or operate machinery while taking it
  • Elderly people are particularly sensitive and have a high risk of falls and confusion
  • Use only for the shortest possible time. Your doctor will review regularly
  • If you have a history of alcohol or substance use problems, discuss this with your doctor
Pregnancy
Diazepam can affect the baby, particularly near delivery. Speak to your doctor immediately if you are pregnant or become pregnant while taking it.
Breastfeeding
Passes into breast milk. Not recommended during breastfeeding.

Medicines and substances that can interact with it

Always tell your doctor and pharmacist about every medicine, supplement, and herbal remedy you take, including those bought without a prescription.
  • Alcohol: A dangerous combination. Both suppress the nervous system and breathing, and the combined effect is much stronger than either alone.
  • Opioid pain medicines: A potentially life-threatening combination that significantly increases the risk of breathing failure.
  • Other sedating medicines: Any medicine that causes drowsiness will have a significantly amplified effect when combined with diazepam.

What your doctor will monitor

  • Your doctor should review the need for diazepam at one and two weeks. Treatment beyond four weeks requires a documented plan for reduction and stopping.
  • Signs of dependence should be reported honestly
  • If you are elderly, your doctor will assess fall risk

What happens if you stop taking it?

Never stop diazepam suddenly after regular use of more than a few weeks. Withdrawal can cause anxiety, insomnia, and in severe cases, seizures. Your doctor will plan a gradual reduction.

What you should know about this medicine in Kenya

Diazepam is one of the most widely prescribed medicines in Kenya, accessible from dispensary level. It is genuinely valuable for acute seizure management, alcohol withdrawal, and procedural use in emergency settings.

Inappropriate long-term prescribing for chronic anxiety and insomnia is a recognised problem in Kenya and globally. The answer to ongoing anxiety is not long-term diazepam. It is addressing what is driving the anxiety.

People who have been on diazepam long-term and want to stop should seek support from their healthcare provider, stopping without guidance is not safe.

References

  1. Ministry of Health, Kenya. (2023). Kenya Essential Medicines List 2023. Nairobi: Ministry of Health.
  2. Ministry of Health, Kenya. (2023). Kenya National Medicines Formulary, 1st Edition. Nairobi: Ministry of Health.
  3. World Health Organization. (2023). Model List of Essential Medicines, 23rd Edition. Geneva: WHO.
  4. Government of Kenya. Narcotic Drugs and Psychotropic Substances Act (Cap 245).